Last updated on 23-8-2019 by Anonymous (non vérifié)
Peer reviewed scientific article
Anglais
SCIENSANO
Auteurs
H Tima Giresse; Al Dulayymi, Juma''a Raheem; Olivier J Denis; Pauline Lehebel; Baols, Klarah Sherzad; Mohammed Omar Mohsin; L'Homme, Laurent; Sahb, Mohaned Mohammed; Potemberg, Georges; Legrand, Sylvie; Lang, Roland; Beyaert, Rudi; Piette, Jacques; Baird, Mark Stephen; Huygen, Kris; Marta RomanoMots-clés
Résumé:
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycolic acids (MAs; alpha-, keto-, and methoxy-) and sugars (trehalose, glucose, and arabinose). Studies using mutant Mtb strains have shown that the structure of MAs influences the inflammatory potential of these glycolipids. As mutant Mtb strains possess a complex mixture of glycolipids, we analysed the inflammatory potential of single classes of mycolate esters of the Mtb cell wall using 38 different synthetic analogues. Our results show that synthetic trehalose dimycolate (TDM) and trehalose, …