Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

Last updated on 23-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article





Accumulating evidence suggests that the bactericidal activity of some antibiotics may not be directly initiated by target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as hypoxia and starvation. This suggests that the target inhibition may not fully explain the bactericidal activity of the drug. Here, we report that INH rapidly increased BCG cellular ATP levels and enhanced oxygen consumption. The INH-triggered ATP increase and bactericid…

Associated health topics:

QR code

QR code for this page URL