KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation.

Last updated on 23-3-2023 by Elena Debock

Public Access

Published

Peer reviewed scientific article

Anglais

SCIENSANO

Résumé:

In previous studies, we identified KLHL12 as a novel interaction partner of the dopamine D4 receptor that functions as an adaptor in a Cullin3-based E3 ubiquitin ligase complex to target the receptor for ubiquitination. In this study, we show that KLHL12 promotes poly-ubiquitination of the receptor by performing ubiquitination assays in eukaryotic cells. Furthermore, we demonstrate that KLHL12 not only interacts with both immature, ER-associated and mature, plasma membrane-associated D4 receptors, but also promotes ubiquitination of both receptor subpools. Unexpectedly, however, KLHL12-medi…

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