MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.

Last updated on 23-8-2019 by Anonymous (non vérifié)

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Peer reviewed scientific article




MALT1 is involved in the activation of immune responses as well as in the proliferation and survival of certain cancer cells. MALT1 acts as a scaffold protein for NF-κB signalling and a cysteine protease that cleaves substrates, further promoting the expression of immunoregulatory genes. Deregulated MALT1 activity has been associated with autoimmunity and cancer, implicating MALT1 as a new therapeutic target. While MALT1 deficiency has been shown to protect against experimental autoimmune encephalomyelitis, nothing is known about the impact of MALT1 on virus infection in the central n…

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