New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test

Last updated on 15-12-2020 by Jill Alexandre

Peer reviewed scientific article

Anglais

SCIENSANO

Article written during project(s) : 

Résumé:

A large number of computer-based prediction methods to determine the potential of chemicals to induce mutations at the gene level has been developed over the last decades. Conversely, only few such methods are currently available to predict potential structural and numerical chromosome aberrations. Even fewer of these are based on the preferred testing method for this endpoint, i.e. the micronucleus test. For the present work, in vivo micronucleus test results of 718 structurally diverse compounds were collected and applied for the construction of new models by means of …

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