Oral fluid for the serological and molecular diagnosis of measles.

Last updated on 23-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article



OBJECTIVES: Since measles presents mostly in children, a non-invasive sample collection technique such as oral fluid sampling would be very useful in the early detection of measles RNA and antibodies. The aim of this study was to validate the detection of anti-measles IgM and measles virus RNA in oral fluid and to make a comparison with the gold standard methods of ELISA using serum (Enzygnost(®) anti-Measles IgM) and in-house nested reverse transcriptase polymerase chain reaction (RT-PCR) using nasopharyngeal secretions.METHODS: Three samples each from 73 measles-positive and 44 measles-ne…

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