Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy87

Last updated on 23-8-2019 by Anonymous (non vérifié)

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Data on the optimal amikacin regimen during continuous renal replacement therapy (CRRT) are scarce and the proposed loading dose of 10mg/kg may result in inadequate drug levels. The aim of this study was to describe the pharmacokinetics of a 25 mg/kg first dose of amikacin in septic shock patients treated with CRRT. Serum samples were collected before (t=0 h) and at 1 (peak), 1.5, 4.5, 8 and 24 h after a 30-min amikacin infusion in 13 consecutive patients treated with a combination of amikacin and beta-lactam. Blood amikacin levels were measured using a validated fluorescence polarisation i…

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