Replicative fitness recuperation of a recombinant murine norovirus - reciprocity of genetic shift and drift.

Last updated on 5-1-2022 by Elisabeth Mathijs

Public Access


Peer reviewed scientific article



Noroviruses are recognized as the major cause of non-bacterial gastroenteritis in humans. Molecular mechanisms driving norovirus evolution are the accumulation of point mutations and recombination. Recombination can create considerable changes in a viral genome, potentially eliciting a fitness cost, which must be compensated via the adaptive capacity of a recombinant virus. We previously described replicative fitness reduction of the first generated WU20-CW1 recombinant murine norovirus, RecMNV. In this follow-up study, RecMNV’s capability of replicative fitness recuperation and genetic cha…

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