Last updated on 14-12-2020 by Jill Alexandre
Auteurs
EFSA Panel on Contaminants in the Food Chain (CONTAM),; Schrenk, Dieter; Bodin, Laurent; Chipman, James; del Mazo, Jesús; Grasl‐Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius; Leblanc, Jean‐Charles; Nebbia, Carlo; Nielsen, Elsa; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Schwerdtle, Tanja; Vleminckx, Christiane; Wallace, Heather; Alexander, Jan; Dall'Asta, Chiara; Mally, Angela; Metzler, Manfred; Binaglia, Marco; Horváth, Zsuzsanna; Steinkellner, Hans; Bignami, MargheritaMots-clés
Résumé:
The European Commission asked EFSA to update their 2006 opinion on ochratoxin A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and found as a contaminant in various foods. OTA causes kidney toxicity in different animal species and kidney tumours in rodents. OTA is genotoxic both in vitro and in vivo; however, the mechanisms of genotoxicity are unclear. Direct and indirect genotoxic and non‐genotoxic modes of action might each contribute to tumour formation. Since recent studies have raised uncertainty regarding t…