The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer

Last updated on 23-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article

Anglais

SCIENSANO

Résumé:

Chronic inflammation may increase the risk to develop cancer, for instance esophagitis or gastritis may lead to development of esophageal or gastric cancer, respectively. The key molecules attracting leukocytes to local inflammatory sites are chemokines. We here provide a systematic review on the impact of CXC chemokines (binding the receptors CXCR1, CXCR2, CXCR3 and CXCR4) on the transition of chronic inflammation in the upper gastrointestinal tract to neoplasia. CXCR2 ligands, including GRO-α,β,γ/CXCL1,2,3, ENA-78/CXCL5 and IL-8/CXCL8 chemoattract pro-tumoral neutrophils. In addition, ang…

Associated health topics:

QR code

QR code for this page URL