Ruggedness tests on the high performance liquid chromatography assay of the United States Pharmacopoeia 23 for tetracycline.HCl: comparison of different columns in an interlaboratory approach

Last updated on 23-8-2019 by Anonymous (non vérifié)

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Résumé:

Ruggedness tests were performed on the United States Pharmacopoeia assay for tetracycline.HCl to examine problems previously reported in the literature. The experiments were performed on nine different columns. The effects of four factors selected from the procedure were examined on qualitative responses by performing half-fraction factorial designs at three different ages on each column. The influence of column ageing was separately evaluated by injections under nominal method conditions at different ages. The C-8 columns gave a separation that was as good as, or better than, the C-18 ones…

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