Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine36497

Last updated on 23-8-2019 by Anonymous (non vérifié)

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Peer reviewed scientific article


Identification and investigation of novel classes and compounds for the treatment of tuberculosis remains of utmost importance in the fight against the disease. Despite many efforts, the weakly gram positive Mycobacterium tuberculosis keeps demanding its toll in human lives. For this reason a small library of substituted and unsubstituted aza analogues of cleistopholine and sampangine were synthesized in a short and straightforward manner and tested in vitro against M.tb. The compounds showed promising activity against the M.tb H37Rv strain and Minimal Inhibitory Concentrations (MIC) could …

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