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Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.

Because the in vivo effectiveness of ligands may also be determined by the rate by which they dissociate from their target receptors, drug candidates are being increasingly screened for this kinetic ...

Non-competitive interaction between raclopride and spiperone on human D-receptors in intact Chinese hamster ovary cells.

experiments, this is not the case for spiperone. Kinetic studies reveal that the binding of raclopride at its high affinity sites does not affect the association of subsequently added [(3)H]-spiperone nor the ...

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice.

Kris Source: J Clin Invest, Volume 119, Issue 6, p.1626-37 (2009) Keywords: Animals Disease Models, Animal DNA-Binding Proteins Immunity, Innate Kinetics Liver X Receptors mice Mice, Inbred C57BL Mice, ...

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