Résultats de la recherche - 10 results

Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals.

reliance on experimental animals, new approach methodologies (NAM s) that provide human-relevant dose-response data are needed. Two transcriptomic biomarkers, GENOMARK and TG x- DDI, have shown a high ...

The GENOMARK transcriptomic biomarker: a new approach methodology for genotoxicity (Qualitative and quantitative aspects)

Source: Joint 3R Symposium 2023 (2023) Keywords: genotoxicity NAMs transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des ...

A Systematic Review on Pollutant Induced Cardiotoxicity: Providing a Toxicological Foundation for NAM Development and Regulatory Acceptance

Publication Type: Scientific poster, presentation or proceeding Authors: T. Roos; C. Leenaars; A. Schaffert; M. Paparella; S. Murugadoss; Birgit Mertens; N. Linzalone; G. Donzelli; M. Ritskes-Hoitinga; R. Gehring Source: 12th World Congress on Alternative ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

methodologies (NAM s) to identify molecular events underlying the genotoxic mode of action of chemicals. Previously, we developed the GENOMARK biomarker, consisting of 84 genes selected based on whole genomics ...

Surveillance van de mortaliteit door alle oorzaken in België, Vlaanderen, Wallonië en Brussel in de zomer van 2020. Be-MOMO The Belgian Mortality Monitoring

jaar en voor personen van 65 jaar en ouder. De ruwe sterftecijfers waren over het algemeen hoger voor mannen. Dit verschil met vrouwen was groter voor mensen onder de 65 jaar en nam af met de leeftijd. ...

The GENOMARK biomarker inhuman HepaRGTM cells: a new approach methodology for genotoxicity assessment

SaferWorldByDesign webinar, Online (2023) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de ...

GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry

International cosmetic congress, Antalya, Turkey (2022) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation ...

RE-Place: A local initiative to pave the road towards international recognition and promotion of new approach methodologies

Database Knowledge sharing NAM Open access replacement Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé ...

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