Résultats de la recherche - 17 results
Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market.
agents, 1 antifungal agent and 1 beta-lactamase inhibitor, covering eleven different antibacterial classes, were selected. The UHPLC- MS screening method with gradient elution is able to selectively detect ...
Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market
selected. The UHPLC- MS2 screening method with gradient elution is able to selectively detect these 36 compounds within 18 min (including wash and equilibration step). It was validated for sensitivity, ...
Analysis of illegal peptide drugs via HILIC-DAD-MS.
five different HILIC columns were selected and screened for their chromatographic performance. Among those columns, the ZIC HILIC column showed the best performance under the tested screening conditions ...
Detection of regulated herbs and plants in plant food supplements and traditional medicines using infrared spectroscopy.
misclassifications for the selected test set. For the other three a success rate of 50% was obtained. Mid- IR combined with SIMCA can therefore be applied as a first step in the screening of unknown samples, before ...
The use of Stationary Phase Optimized Selectivity Liquid Chromatography for the development of herbal fingerprints to detect targeted plants in plant food supplements.
control is performed and that they could contain herbs or plants that are regulated. Stationary Phase Optimized Selectivity Liquid Chromatography (SOS- LC) was evaluated for the development of specific ...
Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).
I Skottheim Rusten Source: CPT Pharmacometrics Syst Pharmacol, Volume 6, Issue 7, p.418-429 (2017) Abstract: Inadequate dose selection for confirmatory trials is currently still one of the most challenging ...
Chemometrics and the identification of counterfeit medicines-A review.
of actual case studies dealing with verifying the authenticity of selected medicines supported by different chemometric approaches. In particular, a general data processing workflow is discussed with ...
Detection and risk evaluation of counterfeit medicines based on physico-chemical properties: the fingerprint and chemometrics approach
a suitable analytical technique can be selected. In the future, this working strategy could potentially be expanded to other pharmacological classes of counterfeit medicines such as sleeping aids and ...
The Monte Carlo validation framework for the discriminant partial least squares model extended with variable selection methods applied to authenticity studies of Viagra® based on chromatographic impurity profiles.
different variable selection schemes: the elimination of uninformative variables, the importance of a variable in projections, selectivity ratio and significance multivariate correlation. The best PLS- DA ...
Comparison of three development approaches for Stationary Phase Optimised Selectivity Liquid Chromatography based screening methods Part II: A group of structural analogues (PDE-5 inhibitors in food supplements).
adulterated dietary supplements, based on Stationary Phase Optimised Selectivity Liquid Chromatography were compared for their easiness/speed of development and the performance of the optimal method obtained. ...