Résultats de la recherche - 28 results
Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market.
quantification method was validated for the positive hits found during screening tests of suspected illegal samples. This resulted in a validation set of 11 antimicrobials and 1 beta-lactamase inhibitor. The ...
Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market
some SF-antimicrobials may include more than one antimicrobial component. This quantification method was validated for the positive hits found during screening tests of suspected illegal samples. This ...
Analysis of illegal peptide drugs via HILIC-DAD-MS.
five different HILIC columns were selected and screened for their chromatographic performance. Among those columns, the ZIC HILIC column showed the best performance under the tested screening conditions ...
Chemometrics and chromatographic fingerprints to classify plant food supplements according to the content of regulated plants.
using SIMCA and PLS- DA. For each model, misclassification rates for the external test set of maximum one sample could be obtained. The models were applied to five real samples resulting in the ...
Detection of regulated herbs and plants in plant food supplements and traditional medicines using infrared spectroscopy.
IR data, using SIMCA as modelling technique. During validation of the model, using an external test set, 21 of 25 were correctly classified and six of the nine targeted plants showed no ...
Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).
fact that selection of dose for phase III is an estimation problem and should not be addressed via hypothesis testing. Dose selection for phase III trials should be informed by well-designed dose-finding ...
The possibilities of chemometrics in API and counterfeit testing
Publication Type: Scientific poster, presentation or proceeding Authors: Eric Deconinck Source: Counterfeit Symposium EDQM, NA, Issue EDQM, NA (2017) Keywords: Chemometrics Counterfeit Health Topics: Effectiveness and safety of vaccines, medicines and he ...
An application of mass spectrometry for quality control of biologicals: Highly sensitive profiling of plasma residuals in human plasma-derived immunoglobulin.
angiotensinogen, antithrombin- III, complement component C8, …). Those results emphasize that MS screening is a relevant first-line test to prevent any undesired concentration of plasma impurities after a plasma ...
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Humans Kidney Tubules, Proximal Laboratory Proficiency Testing Liver Observer Variation Oligonucleotide Array Sequence Analysis Reproducibility of Results Risk Assessment Time Factors Toxicogenetics ...
Childhood leukaemia near nuclear sites in Belgium, 2002-2008.
hypothesis of a gradient in leukaemia incidence with increasing levels of surrogate exposures was explored by means of focused hypothesis tests and generalized additive models. For the surrogate exposures, ...