Résultats de la recherche - 20 results
Sphaeropsidin A C15-C16 Cross-Metathesis Analogues with Potent Anticancer Activity.
A L; Mathieu, Véronique; Kornienko, Alexander Source: ChemMedChem, Volume 19, Issue 18 (2024) Keywords: Antineoplastic Agents Ascomycota Cell Line, Tumor Cell Proliferation Dose-Response Relationship, ...
Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals.
reliance on experimental animals, new approach methodologies (NAM s) that provide human-relevant dose-response data are needed. Two transcriptomic biomarkers, GENOMARK and TG x- DDI, have shown a high ...
Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals
Source: 57th Congress of the European Societies of Toxicology (Eurotox 2023), Ljubljana, Slovenia (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health ...
Occurrence of microcystin congeners in surface waters and food in Belgium as a source of exposure to humans
food supplements daily and all year round. Additionally, most users confirmed that they adhered to the recommended dose for consumption as advertised on the label of the product. This result supports our ...
Mixtures of genotoxicants: does the principle of additivity apply?
Keywords: additivity benchmark dose modelling genotoxicity mixtures Mycotoxins Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: Évaluation des risques et de ...
The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRGTM cells
Source: EEMGS meeting, Malaga, Spain (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health Topics: Health and environment Santé et environnement Gezondheid ...
Migration of mineral oil from cardboard packaging for food: Identification of the hazards and assessment of the exposure of the Belgian population
carcinogenic, no adequate dose-response carcinogenicity data are available and consequently, no MOE-based risk assessment could be performed. Two worst‐case scenarios were applied to obtain some preliminary ...
Cumulative diversity dose CDD as an integrated measure of human exposure to biodiversity
Publication Type: Scientific poster, presentation or proceeding Authors: Raf Aerts; An Van Nieuwenhuyse; Marijke Hendrickx; Lucie Hoebeke; Dendoncker,N.; Linard,C.; Dujardin,S.; Verstraeten,W.; Delcloo,A. Source: European One Health/EcoHealth Workshop, Be ...
Scientific opinion on Malachite green in food
and/or mice, and of micronuclei in mice. LMG also induced cII transgene mutations in mouse liver. MG caused a small, not dose-related, increase in thyroid gland follicular adenomas and carcinomas, and of ...
Scientific Opinion on the Risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food
assumed to contribute equally to internal exposures. Nephrotoxicity was consistently observed in rats treated with 3- MCPD. Data on 2- MCPD toxicity were insufficient for dose-response assessments. Chronic ...