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Résultats de la recherche - 74 results
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
Viral Drug Discovery Foot-and-Mouth Disease Models, Theoretical Oximes Ribavirin RNA, Viral Sulfonamides Virus Cultivation Virus Replication Abstract: Foot-and-mouth disease virus (FMDV) is a highly ...
Anti-mycobacterial activity of 1,3-diaryltriazenes.
the triazene 14 was selected with the best biological properties (IC50 = 3.26 μM, NI50 = 24.22 μM, SI = 7.44). The compound 14 showed the ability to inhibit the growth of intracellular replicating ...
2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.
LAM-1 strain and against intracellular replicating M.tb. The study was further extended with a comet assay and a VITOTOX ™ assay to investigate the possibility of observable genotoxic effects caused by ...
1,2,3,4,8,9,10,11-Octahydrobenzo[j]phenanthridine-7,12-diones as New Leads against Mycobacterium tuberculosis
clinically relevant mycobacterial species at submicromolar concentrations. The susceptibility of a multidrug resistant strain toward these compounds and their ability to target intracellular replicating ...
Biological evaluation of diazene derivatives as anti-tubercular compounds.
three compounds showed signs of genotoxicity by VITOTOX or by Comet assay. The study was complemented by demonstration of the inhibition of intracellular replication of M.tb H37R v inside J774 A.1 cells ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
picornaviral polyprotein is essential for viral replication. Therefore, viral proteases are attractive targets for anti-viral therapy. Most assays available for testing proteolytical activity of proteases are ...
The impact of viral tropism and housing conditions on the transmission of three H5/H7 low pathogenic avian influenza viruses in chickens.
Transcriptase Polymerase Chain Reaction RNA, Viral Viral Tropism Abstract: In this study, shedding and transmission of three H5 / H7 low pathogenic avian influenza viruses (LPAIV s) in poultry was characterized ...
Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep.
Outbreaks Europe Female Reassortant Viruses RNA, Viral Serotyping Sheep, Domestic Vaccines, Subunit Viral Vaccines Virus Replication Abstract: Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have ...
Assessment of various parameters to improve MALDI-TOF MS reference spectra libraries constructed for the routine identification of filamentous fungi
libraries that included 30 filamentous fungus species with various architectures characterized by distinct combinations of the following: i) technical replicates, i.e., the number of analyzed deposits for ...
M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.
the two mutants conferred stronger protection against intratracheal M.tb challenge than vaccination with BCG, as indicated by reduced bacterial replication in lungs at 4 to 12 weeks after challenge. ...