Insufficient beta-lactam concentrations in the early phase of severe sepsis and septic shock89

Last updated on 23-8-2019 by Anonymous (non vérifié)

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Résumé:

INTRODUCTION: Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum beta-lactam concentrations when standard dosages are administered. Previous studies on beta-lactam PK have generally excluded the most severely ill patients, or were conducted during the steady-state period of treatment. The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock. METHODS: Open, prospective, multicenter study …

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