Insufficient beta-lactam concentrations in the early phase of severe sepsis and septic shock89

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Public Access


Peer reviewed scientific article


INTRODUCTION: Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum beta-lactam concentrations when standard dosages are administered. Previous studies on beta-lactam PK have generally excluded the most severely ill patients, or were conducted during the steady-state period of treatment. The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock. METHODS: Open, prospective, multicenter study …

Associated health topics:

QR code

QR code for this page URL