The phage-encoded PIT4 protein affects multiple two-component systems of Pseudomonas aeruginosa

Last updated on 22-12-2023 by Elena Debock

Public Access


Peer reviewed scientific article




More and more isolates have become resistant to antibiotics like carbapenem. As a consequence, ranks in the top three of pathogens for which the development of novel antibiotics is the most crucial. The pathogen causes both acute and chronic infections, especially in patients who are the most vulnerable. Therefore, efforts are urgently needed to develop alternative therapies. One path explored in this article is the use of bacteriophages and, more specifically, phage-derived proteins. In this study, a phage-derived protein was studied that impacts key virulence factors of the pathogen via i…

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