Shotgun metagenomics as a ONE Health tool for better protecting human health

Last updated on 14-1-2023 by Mathieu Gand

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SCIENSANO

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Résumé:

Introduction: Open approaches to identify all biological material in a sample without a priori knowing what to look for, could transform the way specific key public health questions can be addressed, in a ONE Health context. Metagenomics is defined as the study of all genetic material within a sample, using sequencing technologies. Shotgun metagenomics is capable of detecting a wide range of microorganisms in a sample, as well as their composing genes such as virulence or antimicrobial resistance (AMR) genes, without prior knowledge, nor the need to isolate. Such approaches could offer effi…

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