Last updated on 23-8-2019 by Anonymous (non vérifié)
Public Access
Published
Auteurs
M. Taha; Vazquez,J.A.; Hong,E.; Bennett,D.E.; Sophie Bertrand; Bukovski,S.; Cafferkey,M.T.; Carion,F.; Christensen,J.J.; Diggle,M.; Edwards,G.; Enriquez,R.; Fazio,C.; Frosch,M.; Heuberger,S.; Hoffmann,S.; Jolley,K.A.; Kadlubowski,M.; Kechrid,A.; Kesanopoulos,K.; Kriz,P.; Lambertsen,L.; Levenet,I.; Musilek,M.; Paragi,M.; Saguer,A.; Skoczynska,A.; Stefanelli,P.; Thulin,S.; Tzanakaki,G.; Unemo,M.; Vogel,U.; Zarantonelli,M.L.Mots-clés
Résumé:
Clinical isolates of Neisseria meningitidis with reduced susceptibility to penicillin G (intermediate isolates, Pen(I)) harbor alterations in the penA gene encoding the penicillin binding protein 2 (PBP2). A 402-bp DNA fragment in the 3’ half of penA was sequenced from a collection of 1,670 meningococcal clinical isolates from 22 countries that spanned 60 years. Phenotyping, genotyping, and the determination of MICs of penicillin G were also performed. A total of 139 different penA alleles were detected with 38 alleles that were highly related, clustered together in maximum-likelihood analy…