Résultats de la recherche - 11 results
Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.
in silico modeling predicts further Alternaria toxins as potential estrogenic factors. Recent studies indicate also an immunosuppressive role of AOH and ATX- II; however, no data are available for the ...
Chemical and toxciological characterization of e-liquid cigarettes
quantitative in silico models. In total, potential genotoxicity activity was predicted for 44 flavourings. Based on information from European databases, genotoxicity could be confirmed for five of these ...
New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test
Emilio Source: Toxicology Letters, Volume 329, Number 84 (2020) Keywords: Chromosome damage genotoxicity In silico model In vivo micronucleus QSAR Abstract: A large number of computer-based prediction ...
Genotoxic evaluation of the liquids present in electronic cigarettes
immunological responses in animal models. Whether these findings are also relevant to humans remains unclear. [Aim] The genotoxic potential of flavouring substances present in e-cigarettes was studied using ...
Performance of in silico models for mutagenicity prediction of food contact materials
Toxicological Sciences, Volume 163, Issue 2 (2018) Keywords: (Q)SAR food contact materials In silico mutagenicity VALIDATION Abstract: In silico methodologies, such as (quantitative) structure-activity ...
Coatings in food contact materials: Potential source of genotoxic contaminants?
context and from the European CH emicals Agency (ECHA) website. In total, 53 substances were identified as genotoxic in both in silico models, of which ten were considered to be of high concern. For most of ...
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances.
methods such as in silico (i.e. computational) techniques gain more and more importance. In the current study, a new prioritization strategy for identifying potentially mutagenic substances was developed ...
A Tale of Tails: Dissecting the Enhancing Effect of Tailed Primers in Real-Time PCR.
conducted a detailed in vitro and in silico analysis of the enhancing effect of primer tailing on 2 well-established foot-and-mouth disease virus (FMDV) RT-qPCR assays using an FMDV reference panel. Tailing ...
In silico epitope analysis of unique and membrane associated proteins from Mycobacterium avium subsp. paratuberculosis for immunogenicity and vaccine evaluation.
evaluated in IFN-γ release assay. In summary, eleven M. avium subsp. paratuberculosis proteins were identified by in silico analysis and need to be further evaluated for their immunodiagnostic and vaccine ...
The origin of biased sequence depth in sequence-independent nucleic acid amplification and optimization for efficient massive parallel sequencing.
biased sequence depth when using random amplification. Avian paramyxovirus type 8 was used as a model RNA virus to investigate these mechanisms. We showed, based on in silico analysis of the sequence depth ...