Résultats de la recherche - 4 results
Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.
inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as ...
Application of whole genome data for in silico evaluation of primers and probes routinely employed for the detection of viral species by RT-qPCR using dengue virus as a case study.
targeted nucleic acid regions. Whole genome sequencing allows to characterize and track such changes, which in turn enables to evaluate, optimize, and (re-)design novel and existing RT-qPCR methods. The ...
Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.
The 2.2 Å crystal structure reveals that this novel homo-dimeric protein has no identifiable structural homologues. Our biochemical data indicate that acidic patches on the convex outer surface bind RN ...
Viral interference of the bacterial RNA metabolism machinery.
this ‘degradosome interacting protein’ or Dip, to adopt an ‘open-claw’ dimeric structure that presents acidic patches on its outer surface which hijack 2 conserved RNA binding sites on the scaffold ...