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Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
activity of BVDV replication complexes (RC s). BBP interacts likely with the fingertip of the pestivirus RdRp at the same position as BPIP, AG110 and LZ37. This indicates that this region is a “hot spot” for ...
Fine quantification of avian influenza H5N1 escape mutant quasispecies populations using mutation-specific real-time PCR.
approach allows in-depth analysis of quasispecies dynamics using large sample sizes. It may also be applied to the dynamics of hot spots of mutations in several genes, such as HA or PB2, and to the early ...
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
binding site as BPIP or VP32947 at the top of the finger domain of the polymerase that is a “hot spot” for inhibition of pestivirus replication. Health Topics: Animal health Category: A1 FOS ...
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Publication Type: Peer reviewed scientific article Authors: Paeshuyse, Jan; Chezal, Jean-Michel; Froeyen, Matheus; Leyssen, Pieter; Dutartre, Hélène; Vrancken, Robert; Canard, Bruno; Letellier, Carine; Li, Tong; Mittendorfer, Harald; F. Koenen; Pierre Ker ...
The Enrichment of Histomonas meleagridis and Its Pathogen-Specific Protein Analysis: A First Step to Shed Light on Its Virulence.
electrophoresis. For the first time several protein spots were successfully identified. The majority of spots were annotated as cytoskeletal proteins. Actin microfilaments are known to be a key player in cell ...