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Oxidative stress pathways involved in cytotoxicity and genotoxicity of titanium dioxide (TiO2) nanoparticles on cells constitutive of alveolo-capillary barrier in vitro.
for further physiological effects including genotoxicity and cytotoxicity. Within activated pathways, HSP27 and SAPK / JNK proteins appeared as potential biomarkers of intracellular stress and of ...
Evaluation of the genotoxicity and cytotoxicity of semipurified fractions from the Mediterranean brown algae, Dictyopteris membranacea
4, Number S399 (2016) Keywords: cytotoxicity Dictyopteris membranacea genotoxicity micronucleus Test Vitotox test Service: Risques chimiques et physiques pour la santé Chemische en fysische ...
A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus.
alternative to pre-emptive culling or emergency vaccination we further explore the possibility to use antiviral drugs in the event of an FMD outbreak. In the present study, we tested the in vitro cytotoxicity ...
DNA vaccines against tuberculosis.
Antigens, Bacterial BCG Vaccine Humans Immunization, Secondary Mycobacterium tuberculosis T-Lymphocytes, Cytotoxic Tuberculosis, Pulmonary Vaccination Vaccines, DNA Abstract: INTRODUCTION: Tuberculosis (TB) ...
Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge.
infection. DNA plasmid-based vaccines represent a new approach for controlling infectious diseases. In rodents, DNA vaccines have been shown to induce B cell and cytotoxic T cell responses and protect against ...
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
the substituents on the two 1H-benzimidazole groups of BBP resulted in analogues equipotent in anti- BVDV activity (EC50 =0.7±0.1μM), devoid of cytotoxicity (S.I.=142). BBP resistant BVDV was selected ...
Anti-mycobacterial activity of 1,3-diaryltriazenes.
as Mycobacterium bovis, Mycobacterium avium and Mycobacterium ulcerans. Although the library of the compounds showed a considerable acute cytotoxicity, a genotoxicity could not be observed. Finally, ...
Biosafety of Gene Therapy Vectors Derived From Herpes Simplex Virus Type 14581
the other hand, other HSV-1 derived vectors which also have a promising perspective in the clinic, are designed to have enhanced cytotoxicity in certain cell types, as in the case of oncolytic vectors. ...
Biological evaluation of bisbenzaldehydes against four Mycobacterium species.
an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no ...
Investigation into the genotoxicity of water extracts from Hypoxis species and a commercially available Hypoxis preparation.
assay in human hepatoma HepG2 cells. The relative cytotoxicity of these samples was established by determining their NI50 values (50% inhibition of NRU), and these results were used for dose-finding in ...