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Zoekresultaten - 6 results
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Villeret,V.; Wohlkonig,A.; Wintjens,R.; Soror,S.H.; Christophe,T.; Jeon,H.K.; Locht,C.; Brodin,P.; Deprez,B.; Baulard,A.R.; Willand,N. Source: J.Med.Chem., Volume 55, Issue 1, Number 83, p.68- 83 (2012) ...
Synthetic EthR inhibitors boost antituberculous activity of ethionamide36849
Delcroix,G.; Frenois,F.; Aumercier,M.; Locht,C.; Villeret,V.; Deprez,B.; Baulard,A.R. Source: Nat.Med., Volume 15, Issue 5, Number 544, p.537- 544 (2009) Keywords: 0 a Activity Agent Agents Animals antagonists ...
Three-year population-based evaluation of standardized mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing of Mycobacterium tuberculosis
C. Locht, S. Niemann, and P. Supply, J. Clin. Microbiol. 45:691-697, 2007). Here, we evaluated these optimized formats in a much larger population-based study conducted during 39 months in the Brussels ...
Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis36767
Bifani,P.; Kurepina,N.; B.N. Kreiswirth; Sola,C.; Rastogi,N.; Vatin,V.; M.C. Gutierrez; M. Fauville; Niemann,S.; R.A. Skuce; K. Kremer; Locht,C.; D. van Soolingen Source: J.Clin.Microbiol., Volume 44, Issue ...
Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence.
Publication Type: Peer reviewed scientific article Authors: Peirs, Priska; Lefèvre, Philippe; Samira Boarbi; Wang, Xiao-Ming; Olivier J Denis; Braibant, Martine; Pethe, Kevin; Locht, Camille; ...
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Locht, Camille; Brodin, Priscille; Gitzinger, Marc; Déprez, Benoit; Willand, Nicolas; Baulard, Alain R Source: Science, Volume 355, Issue 6330, p.1206-1211 (2017) Abstract: Antibiotic resistance is one of ...