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Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor.

Publication Type: Peer reviewed scientific article Authors: Vrancken, Robert; Andy Haegeman; Paeshuyse, Jan; Puerstinger, Gerhard; Rozenski, Jef; Wright, Matthew; Marylène Tignon; Le Potier, Marie-Frédérique; Neyts, Johan; F. Koenen Source: J Gen Virol, V ...

Efficacy of an inactivated and a fowlpox-vectored vaccine in Muscovy ducks against an Asian H5N1 highly pathogenic avian influenza viral challenge.

viral load in the swabs, but the reduction was higher with the H5N9-It vaccine. The inactivated vaccine induced hemagglutination inhibition (HI) titers (5.4 log2) that were boosted after the second ...

2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.

2’-C-MetCyt resulted in a (1.6-3.2)x10(3)-fold reduction of infectious virus yield. Time-of-drug addition experiments suggest that 2’-C-MetCyt interacts with viral replication at a time point that coincides ...

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.

[4,5-c]pyridine (BPIP). The 50% effective concentration (EC50) for inhibition of bovine viral diarrhea virus (BVDV)-induced cytopathic effect formation was 0.04 +/- 0.01 microM. Comparable reduction of viral RNA ...

Prime-boost strategies combining DNA and inactivated vaccines confer high immunity and protection in cattle against bovine herpesvirus-1.

significantly enhanced virological protection as compared to controls. The 4-logarithms reduction of virus shedding observed in primed-boosted animals was comparable to the one previously reported in calves ...

Inhibition of bovine sperm-zona binding by bovine herpesvirus-1.

anti-gD caused a reduction of this inhibition. Further evidence for the involvement of gC and gD in the virus-sperm interaction was provided by the fact that purified gC and gD decreased sperm-zona binding ...

Binding and entry characteristics of porcine circovirus 2 in cells of the porcine monocytic line 3D4/31.

s co-localized with clathrin. PCV2 infection was decreased significantly by chemical inhibitors that specifically blocked (i) actin-dependent processes, including cytochalasin D (75.5+/-7.0 % reduction) and ...

Arcobacter cibarius sp. nov., isolated from broiler carcasses.

catalase, oxidase and urease activities; reduction of nitrate; growth at 25 and 37 degrees C under aerobic conditions; growth on 2-4 % (w/v) NaCl media; and susceptibility to cephalothin. These data ...

Streptomycin as a selective agent to facilitate recovery and isolation of introduced and indigenous Sphingomonas from environmental samples.

showing that the capacity to resist high concentrations of Sm is a common characteristic within Sphingomonas. Incorporation of Sm into the mineral medium led to a significant reduction in the background ...

Efficacy of E2-sub-unit marker and C-strain vaccines in reducing horizontal transmission of classical swine fever virus in weaner pigs.

vaccines. To evaluate the reduction of the horizontal virus transmission, three comparable experiments were carried out in which groups of weaner pigs (vaccinated with a marker vaccine or a C-strain vaccine) ...

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