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Zoekresultaten - 69 results
Multinomial additive hazard model to assess the disability burden using cross-sectional data.
model must be used with care for populations with low marginal disability probabilities and with high sum of conditional probabilities, especially with small sample size. For illustration, we apply the ...
Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).
issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. In an effort to shift the ...
Model-Based Classification for Digital PCR: Your Umbrella for Rain.
of precision, both at individual partition level and at the level of the global concentration. We illustrate our method on genetically modified organism, inhibition, dynamic range, and mutation ...
An integrated strategy combining DNA walking and NGS to detect GMO
Second, the potential impacts of food processing were investigated using rice noodle samples. Finally, GMO mixtures and a real-life sample were analyzed to illustrate the applicability of the proposed ...
Ensemble post-processing is a promising method to obtain flexible distributed lag models:: A simulation study of time series of air pollution and daily mortality.
simulation scenario’s and illustrated with data from the National Morbidity, Mortality and Air Pollution Study. Manuscript versions: DOI: http://dx.doi.org/10.1007/s11869-015-0388-6 Version: Published Full ...
Biotech Rice: Current developments and future detection challenges in food and feed chain
system applied to unauthorized GMO. Scope and approach To illustrate this problem, the case of rice, one of the leading staple crops, was investigated. An overview of worldwide developed biotech rice ...
A Refined Guinea Pig Model of Foot-and-Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds.
protection afforded by vaccination. These results validate the suitability of the enhanced GP model for the purpose of initial evaluation of inhibitors of FMDV replication and illustrate the potential of ...
The Monte Carlo validation framework for the discriminant partial least squares model extended with variable selection methods applied to authenticity studies of Viagra® based on chromatographic impurity profiles.
set of samples. In this study, as an illustrative example, 46 authentic Viagra® samples and 97 counterfeit samples were analyzed and described by their impurity profiles that were determined using high ...
Identification of substances migrating from plastic baby bottles using a combination of low-resolution and high-resolution mass spectrometric analysers coupled to gas and liquid chromatography.
molecule, product ion fragments and characteristic isotopic ions. Six illustrative examples are shown to demonstrate the modus operandi and the difficulties encountered during identification. The combination ...
Integrated DNA walking system to characterize a broad spectrum of GMOs in food/feed matrices.
sample containing a low amount of the GM MON863 event, representing a more complex matrix in terms of genome size and sensitivity. Finally, to illustrate its applicability in GMO routine analysis by ...