Comparative dissolution study on counterfeit medicines of PDE-5 inhibitors

Last updated on 22-8-2019 by Anonymous (niet gecontroleerd)

Public Access


Peer reviewed scientific article


Abstract Counterfeit medicines are a growing problem in both developing and industrialised countries. In general the evaluation of these medicines is limited to the identification and the dosage of the active ingredients. In this study in vitro dissolution tests were conducted on two sets of counterfeit medicines containing PDE-5 inhibitors (sildenafil citrate and tadalafil). The dissolution profiles were statistically compared to the ones of the genuine products using the f2-method and a comparison at each time point using the Cochran test. The results showed low equivalences between count…

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