Development of a data-intensive centralized system for surveillance and outbreak investigation of bacterial pathogens using whole-genome sequencing

Last updated on 23-1-2023 by Bert Bogaerts

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Whole genome sequencing (WGS), the sequencing of (nearly) complete genomes, has had an enormous impact on almost all fields of biology. However, its successful integration into routine public health practice has lagged behind, partially due to a lack of bioinformatics expertise and suitable bioinformatics workflows. This thesis aims to address the bottlenecks in the WGS data analysis and demonstrate its added value for routine public health surveillance of bacterial pathogens by developing and integrating data analysis methods that fulfill the requirements of a public health institute. Addi…

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