Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK651

Last updated on 22-8-2019 by Anonymous (niet gecontroleerd)

Public Access


Peer reviewed scientific article


The multifunctional AMPK-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor that plays an important role in cell proliferation, growth, and survival. It remains unclear whether AMPK functions as a tumor suppressor or a contextual oncogene. This is because although on one hand active AMPK inhibits mammalian target of rapamycin (mTOR) and lipogenesis–two crucial arms of cancer growth–AMPK also ensures viability by metabolic reprogramming in cancer cells. AMPK activation by two indirect AMPK agonists AICAR and metformin (now in over 50 clinical trials on cancer) has…

Associated health topics:

QR code

QR code for this page URL