Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad.

Last updated on 12-12-2020 by Kim Van Roey

Peer reviewed scientific article




It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoing internal changes of state. Subcomponents of these cellular complexes are assembled into molecular switches. Many of these switches employ one or more short peptide motifs as toggles that can move between one or more sites within the switch system, the simplest being on-off switches. Paradoxically, these motif modules (termed short linear motifs or SLiMs) are both hugely abundan…

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