Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia36836

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

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Samenvatting:

BACKGROUND: Aspergillus fumigatus is the most common agent of invasive aspergillosis, a feared complication in severely immunocompromised patients. Despite the recent commercialisation of new antifungal drugs, the prognosis for this infection remains uncertain. Thus, there is a real need to discover new targets for therapy. Particular attention has been paid to the biochemical composition and organisation of the fungal cell wall, because it mediates the host-fungus interplay. Conidia, which are responsible for infections, have melanin as one of the cell wall components. Melanin has been est…

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