Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

Last updated on 21-10-2023 by Birgit Mertens

Public Access


Peer reviewed scientific article


Article written during project(s) : 


Transcriptomics-based biomarkers are promising new approach methodologies (NAMs) to identify molecular events underlying the genotoxic mode of action of chemicals. Previously, we developed the GENOMARK biomarker, consisting of 84 genes selected based on whole genomics DNA microarray profiles of 24 (non-)genotoxic reference chemicals covering different modes of action in metabolically competent human HepaRG™ cells. In the present study, new prediction models for genotoxicity were developed based on an extended reference dataset of 38 chemicals including existing as well as newly generated ge…

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