Proof-of-concept study of a new LC-ESI-MS/MS-based assay to identify Aspergillus spp. in artificially mixed samples using species/genus-specific proteotypic peptides

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Public Access


Peer reviewed scientific article


Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) identification of microorganisms has shown its usefulness in clinical laboratories, but there are some important limitations associated with this technique. In this study, we present proof of concept of a newly developed assay which can resolve most of these MALDI-TOF MS limitations. This assay is based upon multiplex liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for the targeted identification of different species in mixed samples. Four clinically relevant spe…

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