State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Peer reviewed scientific article



Lentiviral vectors (LV) are competent gene transfer vehicles, as used for both research and gene therapy applications, because of their stable integration in non-dividing and dividing cells and long-term transgene expression. Along with our understanding that LV offer solutions for gene therapy, biosafety concerns have uncovered risks due to insertional mutagenesis, the generation of replication competent lentiviruses (RCL) and vector mobilization. Researchers therefore continue to devote significant efforts in designing LV with improved efficacy and biosafety features. The choice of a part…

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