The Vitotox and ToxTracker assays: a two-test combination for quick and reliable assessment of genotoxic hazards

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Peer reviewed scientific article




To ensure human health, it is essential to characterize the genotoxic potential of new chemical entities such as pharmaceutical and cosmetic substances. In a first tier a battery of regulatory accepted in vitro tests is recommended. These tests have a relatively high sensitivity, but a low specificity. Furthermore, they are time-consuming, laborious and require large quantities of the individual chemicals. New assays overcoming these drawbacks are under development, the majority of them being reporter-based assays. In this paper we investigate the performance of two in vitro reporter-based …

Associated health topics:

QR code

QR code for this page URL