The Vitotox and ToxTracker assays: a two-test combination for quick and reliable assessment of genotoxic hazards

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Peer reviewed scientific article

Engels

Samenvatting:

To ensure human health, it is essential to characterize the genotoxic potential of new chemical entities such as pharmaceutical and cosmetic substances. In a first tier a battery of regulatory accepted in vitro tests is recommended. These tests have a relatively high sensitivity, but a low specificity. Furthermore, they are time-consuming, laborious and require large quantities of the individual chemicals. New assays overcoming these drawbacks are under development, the majority of them being reporter-based assays. In this paper we investigate the performance of two in vitro reporter-based …

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