What is the optimal regimen for BCG intravesical therapy? Are six weekly instillations necessary?

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Peer reviewed scientific article

Engels

Samenvatting:

OBJECTIVE: For more than 20 years, BCG intravesical therapy schedule has included 6 weekly instillations. Very few studies have, however, analyzed the rationale of this regimen. We previously demonstrated that intravesical BCG induced an increased peripheral immune response against mycobacterial antigens as compared to pretreatment values. In the present work, we have studied the weekly evolution of this immune response induced by intravesical BCG instillations. MATERIALS AND METHODS: The evolution of the lymphoproliferative response of peripheral blood mononuclear cells against BCG cult…

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