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Zoekresultaten - 76 results

Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting.

DNA prime-protein boost regimen. While DNA immunization, as previously described, induced robust Th1-type cytokine responses, protein-in-adjuvant vaccination elicited very poor cytokine responses, which ...

CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A.

cytokines similar to wild-type mice. Although beta2m-/- mice were more susceptible to M. tuberculosis infection, following vaccination they efficiently controlled bacterial replication in spleen and lungs ...

Cloning of the gene encoding a 22-kilodalton cell surface antigen of Mycobacterium bovis BCG and analysis of its potential for DNA vaccination against tuberculosis.

p.1040-7 (2000) Keywords: Animals Antigens, Bacterial BCG Vaccine Cloning, Molecular Cytokines mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Weight Vaccines, DNA Abstract: Using spleen cells from ...

Comparison of biological activities of natural and recombinant chicken interferon-gamma.

of biologically active ChIFN-gamma and will allow further studies of the immunomodulatory and therapeutic effects of this cytokine in vivo. Health Topics:  Animal health Category:  A1 FOS ...

Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors.

against i.v. challenge with M. tuberculosis H37R v was analyzed. Significant levels of highly Ag-specific Abs and Th1-type cytokines IL-2 and IFN-gamma could be detected following vaccination with each of ...

DNA vaccines against tuberculosis.

cells, Th1 cytokines and cytotoxic T lymphocytes) and was protective in mouse and guinea pig models of mycobacterial disease. Therefore, DNA vaccination holds promise as an effective means of preventing ...

Cross-reactive immune responses against Mycobacterium bovis BCG in mice infected with non-tuberculous mycobacteria belonging to the MAIS-Group.

cytokine production in response to cytoplasmic and secreted antigens from M. bovis BCG. Whereas initial colony-forming unit (CFU) counts of M. intracellulare and M. avium were higher in lungs than in spleen, ...

Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex.

M A Source: Vaccine, Volume 15, Issue 8, Number 833, p.830-3 (1997) Keywords: Animals Antibodies, Bacterial Antigens, Bacterial BCG Vaccine Cell Division Cytokines DNA, Bacterial Injections, Intramuscular mice ...

Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guérin-infected mice.

of CD4 + T cells and their secretion of interleukin 2. The lack of cytotoxic response in H-2d mice cannot be explained by impaired cytokine production or by a defect in Ag presentation by H-2d ...

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