Zoekresultaten - 5 results
Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.
substances could all be assigned to one of the four priority classes (ranging from low to very high concern). Importantly, 19 substances were considered of very high concern due to in vivo genotoxicity. Five ...
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
regulatory accepted batteries for in vitro genotoxicity testing is recognized, they result in a high number of false positives. This has a major impact on society and industries developing novel compounds ...
Coatings in food contact materials: Potential source of genotoxic contaminants?
context and from the European CH emicals Agency (ECHA) website. In total, 53 substances were identified as genotoxic in both in silico models, of which ten were considered to be of high concern. For most of ...
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances.
a case study. By applying our strategy, 106 out of the 1723 substances were assigned ‘high priority’ as they were predicted mutagenic by 4 different (Q) SAR models. Information provided within the models ...
Evaluation of the potential health risks of substances migrating from polycarbonate replacement baby bottles.
Benzhydryl Compounds Bottle Feeding Endocrine disruptors Food Contamination Humans Infant Phenols Plasticizers plastics Polycarboxylate Cement Polymers Risk Assessment Abstract: Since the European Commission ...