Zoekresultaten - 24 results
Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette Refills
investigated in silico with two complementary (quantitative) structure-activity relationship ((Q) SAR) models (Derek Nexus, Sarah Nexus). In total, 57 flavouring components were identified with a structural ...
A new approach to define acceptance limits for hematology in external quality assessment schemes.
their corresponding assigned value (U-scores) was modeled by means of an adaptation of Thompson’s “characteristic function”. Quantile regression was used to investigate the percentiles of the U-scores for ...
Chemometrics and chromatographic fingerprints to classify plant food supplements according to the content of regulated plants.
objective way. Two approaches were followed: (1) a multiclass model, (2) 2-class model for each of the targeted plants separately. For both approaches good classification models were obtained, especially when ...
Detection of regulated herbs and plants in plant food supplements and traditional medicines using infrared spectroscopy.
combination of both. The results show that the screening of herbal preparations or plant food supplements for specific plants, using infrared spectroscopy, is feasible. The best model was obtained with the Mid- ...
Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).
for drug developers and regulators were presented. These methods are described in the present report: they include five advanced methods for data analysis (empirical regression models, pharmacometrics ...
Commentary on the MID3 Good Practices Paper.
Kerwash, Essam; Khan, David; Flora Musuamba Tshinanu; Ine Skottheim Rusten; EMA Modelling and Simulation Working Group Source: CPT Pharmacometrics Syst Pharmacol, Volume 6, Issue 7, p.416-417 (2017) ...
Zona pellucida gene mRNA expression in human oocytes is related to oocyte maturity, zona inner layer retardance and fertilization competence.
response resulted in a noninvasive oocyte fertilization prediction model. LARGE SCALE DATA: Not applicable. LIMITATIONS, REASONS FOR CAUTION: This is a retrospective study and the relation of oocyte mRNA ...
The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.
vivo human embryogenesis. Human embryonic stem cells (hESC) provide an interesting in vitro model to study early human development. Different studies reported discrepant findings on whether HLA-G mRNA ...
An application of mass spectrometry for quality control of biologicals: Highly sensitive profiling of plasma residuals in human plasma-derived immunoglobulin.
at 1ng/mg in Ig, which is below the minimal thrombotic dose of 3ng/mg observed in an in vivo model. Relative label-free quantitation highlighted significant differences in normalized abundances of ...
Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines.
Adjuvants, Immunologic Animals Antigens, Bacterial Cell Wall Humans Immunity, Innate Lectins, C-Type Models, Animal Mycobacterium Pathogen-Associated Molecular Pattern Molecules Protein Binding Signal ...