Zoekresultaten - 15 results
Simultaneous quantification of Ibuprofen and Paracetamol in combined tablet formulations by UV–VIS spectrophotometry and chemometric modelling
– VIS spectrophotometry that will be applied in routine dissolution testing of combined tablet formulations of two analgesics: Ibuprofen and Paracetamol. Two quantitative chemometric models: Principal ...
Mass Spectrometric Fingerprinting to Detect Fraud and Herbal Adulteration in Plant Food Supplements
external test set. Confusion matrices were constructed to provide insight into the modeling predictions. A complimentary evaluation between data obtained using a previously developed Diode Array Detection ...
Illegal medicines observed in the EU
samples, organises specific ring tests, training sessions, symposia and joint market surveillance studies and provides technical guidance for screening and analysis of suspected illegal medicines. To ...
Characterisation and Hazard identification of substandard and Falsified Antimicrobial Drugs. The CantiBio project 2016-2020
the ones of their genuine counterparts. In general, about 30% of the samples contained higher than permitted amounts of impurities. Concerning the dissolution tests, 58% of samples were not compliant as ...
Microbial quality analysis of falsified medicines seized by controling agencies
set out to see if these products were contaminated with bacteria and fungi and performed enumeration tests. Next, we also conducted a series of microbiological assays on those bacterial strains that ...
COMBINATION OF CHEMOMETRICS AND MULTIDIMENSIONAL FINGERPRINTING FOR DETECTION OF REGULATED PLANTS IN PLANT FOOD SUPPLEMENTS
square – discriminate analysis. A minimum of 86% correct classification rate for external test set validation (17 sample for binary dataset and 59 samples for multiclass dataset) was observed for all ...
Multidimensional Chromatographic Fingerprinting Combined with Chemometrics for the Identification of Regulated Plants in Suspicious Plant Food Supplements.
DA) through (a) binary modelling and (b) multiclass modelling. The correct classification rates (ccr%) by cross-validation, modelling, and external test set validation were satisfactory for both ...
Clustering of Tadalafil API Samples According to their Manufacturer in the Context of API Falsification Detection
latter to obtain characteristic data for the different manufacturers, allowing the network laboratories to conduct authenticity tests for future samples, as well as to detect substandard and ...
Multidimensional Fingerprint Development for the Detection of Tribulus terrestris in Plant Food Supplements
5 orthogonal wavelengths were selected. The developed method was tested for specificity in different triturations (½0, 1/15, 1/10, ⅕ and ½). These were prepared using 10 blank matrices and lactose. In most ...
OMCL testing and the API working group: Part of the solution?
manufacturers. Despite the efforts, API testing within the network is limited, compared to the surveillance of finished products. Though it has to be said that the risk for quality deficiencies and falsification ...