Zoekresultaten - 7 results
Pyrogen testing of phage therapeutic products
amoebocyte lysate (LAL) assay and the animal-friendly alternative, the recombinant factor C (rFC) test. However, other (non-endotoxin) pyrogenic substances including compounds of the gram-positive bacterial ...
Validation of an animal-free analytical method for the detection of bacterial endotoxins in human vaccines
assays are suitable for all vaccines tested, although the most appropriate technique of endotoxins quantification depends on the type of vaccine. Health Topics: Effectiveness and safety of vaccines, ...
Development of a multiplex immunoassay for simultaneous detection of antigens in DTaP vaccines
Virtual (2021) Keywords: 3R Vaccine Potency Abstract: Routine batch quality testing before vaccine release, notably for potency evaluation, still relies on animal use for several animal and human vaccines. ...
Chemical and toxciological characterization of e-liquid cigarettes
present in e-liquids with a sweet, buttery taste such as cake, caramel, popcorn (55% in 2017 compared to 27% in 2018). Next, as a test case, the risk of inhaling diacetyl present in e-liquids was ...
Implementation of the serological method for the potency testing for acellular Pertussis vaccine: user's view.
Publication Type: Scientific poster, presentation or proceeding Authors: F Ribaucour Source: Alternatives to animal testing, NA, Issue European Directorate for the Quality of Medicines & ...
Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production
testing, in-process monitoring of TeNT production could benefit from animal and antibody-free analytical tools. In this paper, we describe the development and validation of a new and reliable antibody free ...
Panel discussion on the adoption of 3Rs and non-animal approaches for quality control and batch release testing of these products
Publication Type: Scientific poster, presentation or proceeding Authors: Geneviève Waeterloos Source: https://www.nc3rs.org.uk/events/nc3rs-workshop-implementing-3rs-who-guidelines-understanding-impact-quality-control-and, https://www.nc3rs.org.uk/, Virtu ...