Zoekresultaten - 28 results
Characterisation and Hazard identification of substandard and Falsified Antimicrobial Drugs. The CantiBio project 2016-2020
identifying potential hazards to raise public awareness. Several quality aspects were evaluated. In a first step samples were screened and the dosage of the identified antibiotics was determined. Results showed ...
The strategic change of the API fingerprint programme: from verification of authenticity of API sources to identifying potential quality issues
analysis to Ph. Eur. Monographs, other types of analysis were performed in order to obtain data, allowing to distinct the different API samples according to their origin or manufacturer. The idea was to ...
Substandard and falsified ivermectin tablets obtained for self-medication during the COVID-19 pandemic as a source of potential harm.
One of the candidate antiviral medicines tested was ivermectin. Although several health authorities warned the public against the use of this medicine outside clinical trials, the drug was widely used ...
Microbial quality analysis of falsified medicines seized by controling agencies
have surged by nearly 65%, spanning 142 countries, posing significant threats to the health and well-being of unsuspecting individuals worldwide [100]. While substandard and falsified life-saving ...
Multidimensional chromatographic fingerprinting combined with chemometrics for the identification of regulated plants in suspicious plant food supplements
the Belgian Federal Agency for Medicines and Health Products, were classified using the above developed models. 10 out of 12 samples were suggestively found to be positive by binary modelling whereas 11 ...
COMBINATION OF CHEMOMETRICS AND MULTIDIMENSIONAL FINGERPRINTING FOR DETECTION OF REGULATED PLANTS IN PLANT FOOD SUPPLEMENTS
fingerprints by performing a correlation analysis on the DAD data. Chemometric analysis was carried out using two approaches: 1. binary models for each plant separately and 2. multiclass models. The data were ...
Multidimensional Chromatographic Fingerprinting Combined with Chemometrics for the Identification of Regulated Plants in Suspicious Plant Food Supplements.
were recorded using ultra-high-performance liquid chromatography (UHPLC) coupled with diode array detection (DAD). Chemometric modelling was performed by partial least squares-discriminant analysis (PLS- ...
Clustering of Tadalafil API Samples According to their Manufacturer in the Context of API Falsification Detection
falsified samples. In total, 46 tadalafil API samples from 13 different manufacturers were collected. For all samples fingerprint data was collected through analysis of impurities and residual solvents, mass ...
Multidimensional Fingerprint Development for the Detection of Tribulus terrestris in Plant Food Supplements
5 orthogonal wavelengths were selected. The developed method was tested for specificity in different triturations (½0, 1/15, 1/10, ⅕ and ½). These were prepared using 10 blank matrices and lactose. In most ...
CHROMATOGRAPHIC FINGERPRINT DEVELOPMENT FOR THE DETECTION OF TRIBULUS TERRESTRIS IN PLANT FOOD SUPPLEMENTS
by preparing triturations of TT with herbal matrices in varying ratios (½, ⅕, 1/10, 1/15, ½0). Twenty unknown samples were screened for TT and further confirmation was carried out by UH ¨ PLC-mass ...