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Zoekresultaten - 39 results

Microbiological and molecular assessment of bacteriophage ISP for the control of Staphylococcus aureus

the isolates, including relevant MRSA strains. From a phage therapy perspective, the infection parameters and the frequency of bacterial mutations conferring ISP resistance were determined. Further, ISP ...

Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Proteins Drug Resistance, Bacterial Folic Acid Humans Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Structure-Activity Relationship Thymidylate Synthase Thymine Abstract: The emergence of ...

Mutations associated with para-aminosalicylic acid (PAS) resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis

Bifani,P. Source: 7ème journée des Doctorants, NA, Issue Université Libre de Bruxelles (ULB), NA (2007) Keywords: acid Clinical de Mutation Mycobacterium Mycobacterium tuberculosis Pa PAS resistance ...

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate ...

Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei.

fluoroquinolone-resistant S. sonnei. We reaffirm that extant resistant organisms belong to a single clonal expansion event. Our results indicate that sequential accumulation of defining mutations (gyrA- S83L, parC- S80I, and ...

Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.

Egypt before disseminating into Northern, Southern and Western Africa, then to the Middle East, Asia and the European Union. The MDR clone has since accumulated various substitution mutations in the ...

Whole-genome-based phylogenomic analysis of the Belgian 2016-2017 influenza A(H3N2) outbreak season allows improved surveillance.

Organization (WHO) and European Centre for Disease Prevention and Control (ECDC) guidelines is based on combining certain genotypic amino acid mutations and phylogenetic analysis. Next-generation sequencing ...

Optimization and Application of a Multiplex Digital PCR Assay for the Detection of SARS-CoV-2 Variants of Concern in Belgian Influent Wastewater.

of emerging SARS-CoV-2 variants of concern (VOC) in influent wastewater (IWW) samples. Key mutations were targeted in the different VOC strains, including SΔ69 /70 deletion, N501Y, SΔ241 and SΔ157. The ...

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