Optimization and validation of an analytical method for the quantification of short- and medium-chained chlorinated paraffins in food by gas chromatography-mass spectrometry

Last updated on 28-5-2021 by Jill Alexandre

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Peer reviewed scientific article

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This work describes the optimization and validation of an analytical method for the quantification of short- and medium-chained chlorinated paraffins (SCCPs and MCCPs, respectively) in a range of food matrices using gas chromatography-electron capture negative ionization-mass spectrometry (GC-ECNI/MS). A dispersive solid phase extraction (dSPE) method was optimized for fish, meat, oil, milk and whole-grain cereal followed by clean-up with concentrated sulfuric acid and acid silica. Fractionation using silica cartridges efficiently removed a number of potentially interfering halogenated comp…

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