Short-term biodistribution and clearance of intravenously administered silica nanoparticles

Last updated on 20-1-2021 by Jill Alexandre

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Peer reviewed scientific article



Recently, concerns have been raised about potential adverse effects of synthetic amorphous silica, commonly used as food additive (E551), since silica nanoparticles have been detected in food containing E551. We examined the biodistribution and excretion in female Sprague-Dawley rats of NM-200, a well characterized nanostructured silica representative for food applications. A single intravenous injection of NM-200 was applied at a dose of 20 mg/kgbw, followed by autopsy after 6 and 24 hours. The main organs where silicon accumulated were liver and spleen. The silicon concentration significa…

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