Zoekresultaten - 8 results
The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.
107/15,667 (0·7%) were deemed consistent with susceptibility. For rifampicin, isoniazid, ethambutol, fluoroquinolones, and streptomycin, the mutations’ pooled sensitivity was >80%. Specificity was over 95% ...
Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.
sensitive and 99%, 100%, 99%, 99% specific for rifampicin, isoniazid, pyrazinamide and ethambutol resistance prediction respectively. We benchmark against four other tools on 10207 (=5845+4362) samples, and ...
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.
profiles; phenotypic resistance to isoniazid, rifampicin, ethambutol, pyrazinamide, and capreomycin; and corresponding drug resistance mutations. We whole-genome sequenced all Mycobacterium tuberculosis ...
Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.
at least rifampicin, isoniazid, any fluoroquinolone and one of the injectable anti-tuberculosis drugs, remains a worldwide public health threat. Among repurposed drugs empirically used for XDR- TB ...
MALDI-TOF for the identification of Mycobacteria and their drug resistance profiles
Mycobacteria. 34 clinical M. tuberculosis isolates were investigated for their resistance profile to four different drugs (rifampicin, isoniazid, ethambutol and linezolid), yielding a 100% concordance to the ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
using the approach called RNA tag-Seq, multiple samples were combined in one run, reducing time and cost. Material/methods: For each drug (isoniazid, rifampicin, ethambutol, capreomycin, amikacin, ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
multiple samples were combined in one run, reducing time and cost. Material/methods: For each drug (isoniazid, rifampicin, ethambutol, capreomycin, amikacin, linezolid, moxifloxacin and bedaquilin), twice ...
RNA-based drug susceptibility testing of Mycobacterium tuberculosis
of RNA biomarkers for ten 1st-line, 2nd-line and new drugs. Taking isoniazid as proof of principle, we present a biomarker set of 5 responsive genes and 3 normalizing genes, which enables to ...